Our Isolation Platform

Biological Dynamics's proprietary lab-on-a-chip (LOC) platform, Verita™ uses  AC Electrokinetics (ACE) technology for isolation of nanoparticles and macromolecules from biofluids, such as whole blood, plasma and serum.

The platform is unique in its use of the direct-to-analyte approach for nanoparticles isolation. This approach removes the need for lengthy sample prep or dilution required by other platforms.

 in whole blood, serum or plasma samples, the platform isolates naturally occurring (endogenous) nanoparticles and biomolecules within 50nm - 1000nm range, such as cell free DNA, extracellular vesicles, and aggregated proteins.

in whole blood, serum or plasma samples, the platform isolates naturally occurring (endogenous) nanoparticles and biomolecules within 50nm - 1000nm range, such as cell free DNA, extracellular vesicles, and aggregated proteins.

Our team is utilizing the platform to develop minimally invasive diagnostic assays that detect biomarkers, such as cell-free DNA, exosomes, exo-proteins, and other cellular particles (see publications).

Unique Capabilities of Verita™ Platform

No Sample Prep, No Dilution. The platform offers a direct isolation of nanoparticles in high conductivity solutions, such as unprocessed whole blood, serum and plasma.

Small sample size. Typical sample input is between 50-250µL, depending on the the assay.

Rapid isolation. Most assays takes <1 hr.

How ACE Works

Our platform uses AC Electrokinetics (ACE) to create an electronic size-based band-pass filter capable of inducing a dipole on particles of interest and attracts them to specific locations on a microelectrode array.

The platform uses digital fluorescence microscopy to measure relative concentration of isolated nanoparticles of interest.

The ACE filter is generated using a specific voltage / frequency algorithm and microelectrode array geometry. It isolates particles of interest based on their relative 3D conformation in a fluid matrix and pulls them to specific locations on a microelectrode array.