Verita™ Technology

Biological Dynamics' patented, proprietary semi-conductor based technology, Verita, uses AC Electrokinetics (ACE) for isolation of exosome and extracellular vesicles from biofluids, such as whole blood, plasma and serum. ACE involves three forces, dielectrophoresis, AC Electrothermal Flow, and AC Electroosmosis. The platform is unique in its use of the direct-to-analyte approach for exosome isolation. This approach removes the need for lengthy sample prep or dilution required by other platforms.

The result is that isolation goes from days to hours with minimal force and damage to membranes, high yield and high purity.

How ACE Works

Our platform uses AC Electrokinetics (ACE) to create an electronic size-based band-pass filter capable of inducing a dipole on particles of interest and attracts them to specific locations on a microelectrode array.

The platform uses digital fluorescence microscopy to measure relative concentration of isolated nanoparticles of interest.

The ACE filter is generated using a specific voltage / frequency algorithm and microelectrode array geometry. It isolates particles of interest based on their relative 3D conformation in a fluid matrix and pulls them to specific locations on a microelectrode array.

 

Verita Isolation Capabilities

Our team is using the technology to develop platforms for developing diagnostic assays that detect biomarkers, such as cell-free DNA, exosomes, exo-proteins, and other cellular particles (see publications).

Unique Capabilities of Verita Platform

  • No Sample Prep, No Dilution. Broad access to highly valuable blood-based biomarkers in unprocessed state. The platform isolates nanoparticles in high conductivity solutions, such as unprocessed whole blood (see video left), serum and plasma.

  • Co-detection of multiple classes of biomarkers in the same sample (Examples: cell-free DNA and exosomal proteins)

  • Radically simplified workflow enables commercially viable multi-omic testing for many applications: sample-to-answer assays, small sample sizes (50-250µL for detection assays), quick turnaround and minimal hands-on time.