POSTER PRESENTATION: Friday, May 27, 2022
3:15 PM – 4:15 PM CET
SESSION ROOM: Forum 5 & 6
TITLE: PF01 – Technologies and methods: EV separation from blood

David Searson, Senior Process Engineer, Biological Dynamics to present the company’s latest data for early cancer detection.

PRESENTATION ABSTRACT:
Electrokinetic Isolation of Extracellular Vesicles from Pancreatic, Ovarian and Bladder Cancers Enables Early Detection
Extracellular vesicles (EVs) carry cancer biomarkers and are central to emerging liquid biopsy technologies; however, current EV isolation methods balance purity against efficiency. We investigated an alternating current electrokinetic (ACE) method to isolate EVs directly from plasma. We compared the ACE method against differential ultracentrifugation (DU) to study yield, purity and utility. EVs isolated by ACE were then used for detection of early-stage pancreatic, ovarian, and bladder cancers.

The annual ISEV meeting offers an unparalleled opportunity to learn from, teach, and network with, leading and emerging experts in EV research. The scope and quality of the scientific exchange makes ISEV2022 the world’s largest and the premier meeting in EV research. This event features the best in vesicle science, covering all aspects of fundamental, translational, and clinical research, disseminating cutting-edge developments in EV research. ISEV2022 brings together scientists from academic, clinics, and industry, who have a common goal of understanding EVs and applying this knowledge for societal and economic benefit.