Cancer Detection at your Fingertips: Smartphone-Enabled DNA Testing

This is Biological Dynamic's first publication about the use of Biological Dynamics ACE-based isolation platform for point-of-care applications.

Turner R, Madsen J, Herrera P, Wallace J, Madrigal J, Hinestrosa JP, Dobrovolskaia I, Krishnan R, "Cancer Detection at your Fingertips: Smartphone-Enabled DNA Testing" paper presented to 40th International Engineering in Medicine and Biology Conference in in Honolulu, Hawaii on July 21, 2018.

ABSTRACT: High molecular weight cell-free DNA (hmw cfDNA) found in biological fluid, such as blood, is a promising biomarker for cancer detection. Due to the abundance of background apoptotic cell-free DNA in blood, quantifying the native concentration of hmw cfDNA using existing methods is technically challenging, time-consuming, and expensive.

We have developed a novel technology which utilizes Alternating Current Electrokinetics (ACE) to isolate hmw cfDNA directly from blood. Furthermore, we integrated this technology into a handheld device which utilizes a smartphone for power, instruction transmission, optical detection, image processing, and data transmission. The detection of hmw cfDNA in blood plasma demonstrated the performance of the device. We are continuing development of this device as a future point of care in vitro diagnostic.