Rapid Electrokinetic Isolation of Cancer-Related Circulating Cell-Free DNA Directly from Blood

The authors used Biological Dynamics AC electrokinetic platform to isolate, to elute and to sequence cell-free DNA from 25 μL unprocessed blood from 15 chronic lymphocytic leukemia (CLL) patients and 3 healthy individuals. The complete process, blood to PCR, required <10 min.

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Dielectrophoretic Isolation and Detection of cfc-DNA Nanoparticulate Biomarkers and Virus from Blood

This study demonstrated the potential clinical relevance of this Biological Dynamics technology for diagnostic applications as a a “seamless sample-to-answer” technique for the rapid detection of cfc-DNA and nanoparticulate biomarkers directly from blood and other complex biological samples.The authors showed rapid isolation and detection of SYBR Green stained cell-free DNA from 20 µL whole blood samples from Chronic Lymphocytic Leukemia (CLL) patients.

Overall the results of this study support the enormous potential of DEP as a “seamless sample-to-answer” technique for the rapid detection of cfc-DNA and nanoparticulate biomarkers directly from blood and other complex biological samples.

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